There is zero mention of sex in my D&D. Never with my kids, and never even when we played as teenagers and young 20-something adults. It was well understood the two don't mix. No half-orcs! (OD&D)
For that matter, there was no sex in comic books and/or sci fi movies in my youth either!
There is also no need to go to the bathroom because human are 100% efficient at turning food into energy.
There were, incidentally, no mosquitoes either (because I hate them)...until I needed a disease vector for a haunted moathouse that looked different inside if you were feverish with plague.
Back to the topic at hand...
In the early 90's my DM and I spent a summer in San Diego and he ran a newspaper ad for D&D players. One person who answered the ad was a gal. Never had an issue. Heck, my DM even ran a second (parallel) group circa 1979, while still in high school and again later college---both had female members.
So in retrospective, all I can say is the when it was an all boys group it used to be more every-man-for-himself and less co-operative (and less polite). But that's a pretty small sample-size to draw any conclusions.
I was originally just speculating of the nature of social norms which goes far beyond D&D, not really about game content...or "player agency". I think you misunderstood me there. I was talking social tendencies as a subconscious bias affecting a DM. I have come to see the fair sex as a civilizing influence on the adolescent male, and wonder if that results in a kinder, gentler D&D automatically. It's hard to imagine it does not. My son plays a more ruthless game than my daughters---that much I see first hand.
I was also alluding to the presence or absence of obsessive, fiddly, rules-oriented, abstracted warfare, and other boring mechanical details that one typically associates with male nerds. I think that's where Prince was going too, "the average male" (if such an animal still exists) versus a (possibly outdated) notion of the "average female". My wife is an amazing, intelligent, beautiful, and strong-willed lady who is the undisputed head of our household. Former electrical engineer. MBA. etc. She would whole heartily agree with Prince---men and women are just different. Exactly how & why we'll probably be debating forever. But it think it wold be a duller, grayer world if the differences between the sexes ever completely disappeared.
One fella I knew in the 1990's told me 20th century Communist China worked at suppressing the differences between the sexes---I don't know if that's true.
There are also probably a whole slew of male dominance cues and the like that would only happen between same-sex peers.
Ultimately, it not important because every group finds it's own social equilibrium. (and I'm probably drifting into politics again)